After Massive Outcry, China Shuts Down Scientist Who Created First Genetically Altered Babies

Bioethics   Micaiah Bilger   Nov 29, 2018   |   7:10PM    Washington, DC

China has ordered a group of scientists to stop their work on genetically-altered babies in the midst of international outcry.

The AP reports the Chinese government issued the order Thursday, saying the scientists’ actions were illegal and an investigation is underway.

Last week, scientist He Jiankui of Shenzhen, China, claimed to have successfully genetically altered the DNA of twins girls. He said he edited the girls’ DNA when they were embryos in an attempt to create a new, HIV-resistant trait.

The girls, Lulu and Nana, were born earlier this month, according to India Today. They are believed to be the first genetically altered human beings alive today; however, He’s experiment has not been confirmed.

Chinese Vice Minister of Science and Technology Xu Nanping condemned He’s work to state broadcaster CCTV this week, saying it “crossed the line of morality and ethics adhered to by the academic community and was shocking and unacceptable.”

A leading group of researchers also expressed strong concerns with the experiment. They said scientists do not yet know the short- and long-term risks of editing human DNA. The potential risks are far-reaching because of the possibility of the DNA modification being passed on to future generations.

In a statement, He said he will “cooperate fully” with the investigations and inquiries about his work.

He’s experiment has been met with strong public outcry by scientists across the world. Last week, Dr. Kiran Musunuru, an expert on gene editing at the University of Pennsylvania, slammed the experiment as dangerous.

It’s “unconscionable … an experiment on human beings that is not morally or ethically defensible,” Musunuru said.

But He countered the concerns by claiming he feels a “strong responsibility” about ending the growing HIV problem.

“I feel a strong responsibility that it’s not just to make a first, but also make it an example,” He told the AP. “Society will decide what to do next” in terms of allowing or forbidding such science.

His experiment has not been verified independently, nor has it been published in a journal, according to the reports. However, a U.S. scientist also was involved in the project: Professor Michael Deem, of Rice University in Texas.

Deem was He’s adviser when he studied in the U.S. He also attended Stanford University before returning to China, where he now runs a lab at Southern University of Science and Technology of China in Shenzhen and two genetics companies, according to the report.

He described his experiment to the AP:

The gene editing occurred during IVF, or lab dish fertilization. First, sperm was “washed” to separate it from semen, the fluid where HIV can lurk. A single sperm was placed into a single egg to create an embryo. Then the gene editing tool was added.

When the embryos were 3 to 5 days old, a few cells were removed and checked for editing. Couples could choose whether to use edited or unedited embryos for pregnancy attempts. In all, 16 of 22 embryos were edited, and 11 embryos were used in six implant attempts before the twin pregnancy was achieved, He said.

Tests suggest that one twin had both copies of the intended gene altered and the other twin had just one altered, with no evidence of harm to other genes, He said. People with one copy of the gene can still get HIV, although some very limited research suggests their health might decline more slowly once they do.

He used CRISPR, a new DNA editing tool, that bioethicists have feared could be used to create “designer babies.” No one yet knows what DNA editing could mean for human beings or their offspring who inherit the modified DNA.

“These mutations could be passed down through the germline to future generations with unknown implications for everyone,” Charlotte Lozier Institute Dr. David Prentice wrote previously.

But scientists have been tinkering with the technology anyway. In 2017, Oregon scientists said they successfully genetically modified human embryos with CRISPR. In that experiment, however, the embryos were created and then destroyed.

David Albert Jones, director of the Anscombe Bioethics Centre in England, previously summed up the problems with this form of human experimentation.

“Instead of treating existing human beings in ways that respect their rights and do not pose excessive risks to them or to future generations, we are manufacturing new human beings for manipulation and quality control, and experimenting on them with the aim of forging greater eugenic control over human reproduction,” Jones wrote.